Despite the fact that untold human suffering has become synonymous with the African continent, the Peace and Security Council of the African Union continues to promote peace, security and stability in Africa. Having been established in 2003 and formally launched in 2004 under the auspices of the African Union, the Peace and Security Council plays a critical role in the implementation of the responsibility to protect. The Peace and Security Council, which is at the epicentre of the African Peace and Security Architecture, has become a beacon of hope in addressing the many conflicts that ravage the continent. This study explores the relationship between the Peace and Security Council and, respectively, the United Nations Security Council, the Pan-African Parliament, the African Commission on Human and Peoples' Rights, civil society organizations and sub-regional mechanisms. The study offers recommendations with a view of making the Peace and Security Council more effective in the fulfilment of its mandate through partnering with these institutions.