The Effect of Adenosine or Diazoxide on Apoptosis, Aquaporin-7 and Glycocalyx integrity during Myocardial Protection in Coron... (Pehmeäkantinen kirja)

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Myocardial dysfunction after coronary bypass surgery (CABG) is associated with ischemia-reperfusion injury (IRI) and tissue damage. Adenosine and Diazoxide are ATP sensitive mitochondrial potassium channel (KATP channel) openers that may have cardioprotective value after myocardial dysfunction and CABG. We evaluated whether Adenosine and Diazoxide added to blood cardioplegia during CABG have a myocardial cardioprotective impact.

This thesis consists, in a double blinded randomized fashion, two sets of hemodynamically stable patients: 1. Patients with stable coronary artery disease (CAD) without recent myocardial infarction treated with Adenosine. During CABG, Adenosine 250 ìg/kg was injected into the aortic root immediately after cross clamping. For myocardial apoptosis, a dUTP nick-end labeling (TUNEL) detection kit was used and expressions of bax and bcl-2 genes were evaluated. 2. Patients had a stable coronary artery disease eligible for elective CABG, but with a history of a recent less than a month old myocardial infarction. Diazoxide 50 µg/l was mixed with blood cardioplegia and injected into the aortic root. Expression of Aquaporin-7 and peripheral plasma levels of syndecan-1 and hyaluronan were investigated.
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