This thesis consists, in a double blinded randomized fashion, two sets of hemodynamically stable patients: 1. Patients with stable coronary artery disease (CAD) without recent myocardial infarction treated with Adenosine. During CABG, Adenosine 250 ìg/kg was injected into the aortic root immediately after cross clamping. For myocardial apoptosis, a dUTP nick-end labeling (TUNEL) detection kit was used and expressions of bax and bcl-2 genes were evaluated. 2. Patients had a stable coronary artery disease eligible for elective CABG, but with a history of a recent less than a month old myocardial infarction. Diazoxide 50 µg/l was mixed with blood cardioplegia and injected into the aortic root. Expression of Aquaporin-7 and peripheral plasma levels of syndecan-1 and hyaluronan were investigated.
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