Pseudogenes and gene Duplications Tell A Story of Evolutionary fates of Animal Alpha Carbonic Anhydrases (Pehmeäkantinen kirja)

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In this study I have examined two subfamilies within metazoan á-CAs, namely the GPI-linked á-CAs in vertebrates and all á-CAs in 12 fruit fly genomes.

Within the GPI-linked subfamily, we characterized biochemically the novel isozyme, murine CA XV, to show that it is a glycosylated, GPI-anchored, membrane protein, similar to CA IV. The expression of gene CA15 was seen in mouse kidney, testis, and brain, similar to human CA4.

Our studies show that CA15 is a pseudogene in primates, with multiple defects seen in different species. Their analysis suggests that the inactivation and 'pseudogenization' of CA15 in primates was probably initiated by a mutation of one of the active-site histidines or an insertion near the active site.
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