Primary progressive multiple sclerosis, Clinical, Immunological and radiological study (Pehmeäkantinen kirja)

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Toimitusaika 3 - 14 arkipäivää

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Multiple sclerosis (MS) that is the most frequent demyelinating disease of the central nervous system (CNS) has very heterogeneous clinical presentations. The majority of patients have relapsing-remitting disease course characterized by episodes of acute exacerbation. Primary progressive MS (PPMS) is a rare subtype of MS which is characterized by a steady progression of irreversible disability from the onset of the disease.

The main goal of this thesis was to identify clinical and immunological features of PPMS and correlate them with magnetic resonance imaging (MRI) findings. The specific aims were the following: 1) to characterize the neurological, cognitive and urological abnormalities in PPMS; 2) to test whether there are specific immunological abnormalities in progressive subtypes of MS; 3) to characterize the volumes of MRI abnormalities in brain and spinal cord in PPMS and 4) to evaluate whether the volumes of focal, diffuse and atrophic central nervous system (CNS) abnormalities in MRI are associated with clinical and immunological features of PPMS.
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