Large chromosomal aberrations are typical for most solid tumors, including pancreatic cancer. Recurrently amplified regions are likely to contain genes which contribute to the development of the disease and might thus serve as targets for early detection or treatment of the disease. Here, a detailed characterization of the 7q21 q22 amplicon in pancreatic cancer was performed in order to identify novel target genes. The amplification was found to exist in 25% of both pancreatic cancer cell lines and primary tumors and to result in overexpression of several genes within the amplicon core. Further functional studies on three of the amplified genes, ARPC1A, ARPC1B, and KPNA7 confirmed that these genes do contribute to the pathogenesis of pancreatic cancer.
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