Evalution of Cardiovascular Risk by Electrocardiographic Variebles (Pehmeäkantinen kirja)

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Cardiovascular diseases are the major cause of death worldwide, and from these coronary heart disease is the most important cause of sudden death. The risk associated with cardiovascular disease can in many ways be estimated from electrocardiogram (ECG). The electrocardiographic variables prolonged QT interval, increased magnitude of T wave alternans (TWA) and higher heart rate (HR) are all associated with increased risk of unfavourable cardiac events.

Prolonged QT interval, and also increased TWA, can be a consequence of genetic variation in cardiac ion channels or other proteins affecting intracellular ion balance. The association of genetic variation with cardiac repolarization, measured as QT interval, has been widely studied, but most of the studies have focused on variables in ECG measured at rest, while systematic studies concerning these associations during exercise or recovery are largely missing. The genetic background of TWA has not been systematically studied.
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