Cognitive Function in Opioid Substitution Treated Patiens (Pehmeäkantinen kirja)

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Opioid substitution treatment (OST) with buprenorphine (BN) or methadone (METH) is the most effective treatment for opioid-dependence. In this study attention, working memory, and episodic memory functioning in OST patients was examined cross-sectionally and longitudinally.

METH patients performed worse in many attention-related reaction time tasks in relation to controls or BN patients. In each drug group, drug treatment variables predicted 10% of the attention performance. In most working memory tests both drug groups performed worse than controls. A group by time interaction in one working memory test in BN patients may indicate improvement of function. Use of benzodiazepine (BZD) medication predicted impaired working memory performance. In verbal episodic memory tests treatment with more than one other psychoactive drug (than opioid or BZD) and frequent substance abuse in the past month predicted 20% of performance. Almost normal cognitive performance in stable OST supports the idea of efficient compensation of the opioid abuse history related neural burden. The results are relevant for patients and prescribers when choosing treatment options or rehabilitation goals.
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