Biomakers for predicting the outcome of Puumala hantavirus infection (Pehmeäkantinen kirja)

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Puumala hantavirus (PUUV) causes a mild type of hemorrhagic fever with renal syndrome called nephropathia epidemica (NE). After an incubation period of 1-8 weeks, NE presents with sudden high fever, headache, nausea, abdominal pain, backache, visual disturbances, and impaired renal function. The severity of NE varies from asymptomatic to rare fatal cases, and its pathogenesis is not completely understood. An important feature in hantaviral infections is capillary leakage due to increased capillary permeability. The mechanisms behind this phenomenon are unclear, although immunological responses have been suggested to be important.

In the present study, the association of immunological factors, i.e. interleukin (IL)-6, C-reactive protein (CRP), pentraxin-3 (PTX3), indoleamine 2,3-dioxygenase (IDO), and cell-free DNA (cf-DNA), with the severity of NE was analyzed. Furthermore, their possible role in the pathogenesis was assessed.
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