Adult-type hypolactasia in North-West Russia (Pehmeäkantinen kirja)

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Adult-type hypolactasia (primary lactose malabsorption, lactase non-persistence) is the most common enzyme deficiency in humans, presenting in all populations and varying considerably by frequency in different ethnicities. Adult-type hypolactasia may lead to unspecific abdominal complaints such as diarrhea, flatulence, audible bowel, nausea, bloating and abdominal cramping. The condition is genetically determined and inherited as a recessive trait. Homozygous subjects with the C/C-13910 genotype evince very low lactase activity in the jejunum, whereas heterozygous C/T-13910 subjects and carriers of the T allele in its homozygous variant (T/T-13910) maintain a higher lactase activity.
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